The supplementary components that make up the mac are

The supplementary components that make up the mac are as follows:

Membrane attack complex

The membrane attack complex Cb5789 in immunology, that is, the membrane attack complex MAC, forms hydrophilic pores on the cell membrane, which can allow water and electrolyte to pass through without allowing protein macromolecules to escape. Eventually, the cell will be dissolved and destroyed due to the change of intracellular osmotic pressure.

Briefly describe the biological function of complement system;

(a) Biological effects of MAC-mediated cell lysis

Complement system activation? Membrane attack complex?

Lyse target cells (such as G- negative bacteria such as Neisseria, abnormal red blood cells, etc.). ).

Practical significance: a. anti-infection;

B. autoimmune diseases.

(2) Biological function mediated by complement activation fragment

1. Regulatory effect

Ag (particle) -Ab composite? C3b、

C4b、iC3b？ Binding to phagocyte CR? Phagocytosis of immune complex.

Practical significance: anti-infection.

2. Immune complex scavenging effect