Luwan High School was founded in 1953. It turned out to be Luwan Middle School. This is the first batch of new complete middle schools established by the Shanghai Municipal People's Government. In 1950s, it was established as the first batch of 10 municipal key middle schools in Shanghai. This century has been listed as the first batch of Shanghai experimental demonstration high schools, national mental health education characteristic schools, municipal science and technology education characteristic demonstration schools, municipal art characteristic schools, municipal civilized units, and Shanghai primary and secondary school mental health education demonstration schools. 1999, the former Luwan Middle School was split into junior high school and senior high school is now Luwan Senior High School.

The school has a team of teachers with advanced ideas, noble ethics and excellent business skills, advanced DIS digital laboratory, digital interactive laboratory, intelligent robot laboratory, planetarium and planetarium, as well as modern information network center, library and data center, student activity center, cultural and sports activity center and mental health service center.

The school is characterized by scientific education experiments and explorations, and has formed a number of first-class scientific and technological education projects in Shanghai, trained a number of students with special skills in science and technology, and achieved excellent results in the Shanghai and national youth scientific and technological innovation competitions for three consecutive years; The quality of school education and teaching has improved year by year, and the enrollment rate of college entrance examination has increased year by year. The college entrance examination rate is 98%, enjoying a good social reputation.