In 1891, George Merck founded Merck & Co., Ltd. in the United States.

In 1903, a pharmaceutical factory was built in New Jersey

In 1933, a research branch was established, becoming the predecessor of the now famous Merck Research Institute

In 1953, with Sha Eastern companies merged and Merck & Co. was formally established.

In 1992, Merck China was established.

In 1993, it acquired Medco and entered the healthcare field

In 1998, Merck established the Office of Business Ethics to ensure that the company's high ethics and values ??continue to be adhered to.

From 1998 to 2000, Merck acquired a series of innovative biotechnology companies, such as Biogen, Synaptic, Vical and Sibia Neurosciences, to further strengthen its scientific research strength.

In March 2009, Merck and Schering-Plough announced a cooperation agreement, with Merck acquiring Schering-Plough for US$41 billion in cash and stock. Currently, the merger of the two companies is still subject to approval by European and American regulatory authorities.

On November 3, 2009, Merck announced that it had completed the merger process with Schering-Plough, and the stocks of the two companies were combined into one.

On November 4, 2009, Merck announced that the new company after the merger of the two companies would officially begin operations.