Nineteen fears refer to the conflict between two drugs with the same properties. One drug will be inhibited by another, thus reducing its efficacy or toxicity, or even completely failing. Eighteen opposites and nineteen fears refer to the opposites and mistakes in the incompatibility of traditional Chinese medicine.

Introduction:

Under the guidance of Chinese traditional medical theory, drugs collected, processed, prepared, explained the mechanism of action and guided clinical application are collectively referred to as traditional Chinese medicine. In short, traditional Chinese medicine refers to substances that are used to prevent, treat and diagnose diseases and have rehabilitation and health care functions under the guidance of traditional Chinese medicine theory.

Traditional Chinese medicine mainly comes from natural medicines and their processed products, including plant medicines, animal medicines, mineral medicines and some chemical and biological products. Because most Chinese medicines are plant medicines, there is a saying that "all medicines are based on grass".

Ninety flavors is a basic theoretical term of traditional Chinese medicine, which means that two drugs can produce or enhance toxicity or side effects when used together.

The melody of "Nineteen Fears" originated from Chun Liu Medical Classic Primary School in the Ming Dynasty. There are 19 kinds of drugs in the melody, namely, sulfur is afraid of nitrate, mercury is afraid of arsenic, clove is afraid of turmeric, wolfsbane is afraid of Lithuania, croton is afraid of morning glory, rhinoceros horn is afraid of Sichuan aconite, kusnezoff monkshood, ginseng is afraid of trogopterori, and Guan Gui is afraid of red stone.

In the preface of Shennong Materia Medica, it is pointed out that "those who are opposed to evil are not available" and "those who are afraid of killing each other are poisonous and should be controlled, so they cannot be used together". Since the Song Dynasty, the relationship of "mutual fear" has also been listed as a compatibility taboo, which is confused with "mutual evil". Therefore, the concept of "nineteen fears" has different meanings from "mutual fear", one of the "seven emotions" mentioned in the section of "Compatibility".

The application of "nine fears";

For the application of the "Nineteen Fears" in medicine, medical scientists in past dynasties have different opinions and opinions. At the same time, citing classics and applying ancient prescriptions proves that some drugs can still be used together. Including modern medicine. Even though there is not much research work, it does prove that even if drugs are used together, the impact will depend on the specific situation.

For example, when licorice and kansui are used together, the toxicity mainly depends on the dosage ratio of licorice; Another example is that Fritillaria and Pinellia ternata are compatible with aconite respectively, and the toxicity is not significantly enhanced. However, the combination of asarum and veratrum can lead to poisoning and death of experimental animals.