Some things need to be given up bravely, and giving up is necessary. This is another kind of persistence. The general meaning of this sentence should be persistence and abandonment.

Because there are some things, we should stick to it when we need it, and don't stick to it when we should give up, because it has no meaning of persistence.

Moreover, it will be more meaningful and valuable to insist on doing something meaningful. If you insist on something you should have given up a long time ago, but you still insist.

Such persistence is meaningless. Besides, persistence is very important, but at the same time, it will be very valuable.

So, the meaning of this sentence is this: stick to what you should stick to and give up what you should give up.