In 1933, he graduated from the Department of Art and Film Studies at Nihon University and joined PCL (the predecessor of Toho). His seniors there, Yamamoto Kajiro and Naruse Mikio, told him that he could learn from the great director Akira Kurosawa. . I met my friend Taniguchi Senkichi again. During World War II, he was drafted into the infantry regiment to participate in the Sino-Japanese War (he was recruited there during the 226 Incident). After the war, Honda was deeply saddened by the news of the death of his entire family. In 1946, he witnessed the atomic bomb attack on Hiroshima while driving. The tragic situation that followed was a strong shock. The great director Akira Kurosawa is his pillar of support. Throughout his directing career, Director Honda always welcomed people with a smile. When the 2004 movie "Godzilla Final Battle" was released, actress Mizuno Kumi, who played Namikawa Reiko, recalled: "Always smiling, he is a very gentle person. . It’s like a Buddha to an actress.”

Honda Inoshiro has shot many special films such as Godzilla and Ultraman.

Honda is a close friend of Akira Kurosawa, and has also worked as an assistant director for the latter's "Yora Dog", "Shadow Warrior", "Ran" and "Dream".

When filming Godzilla, he said a famous saying: "Monsters are born too tall, too strong, and too heavy, and that is their tragedy."