Materia Medica clearly points out the incompatibility of eighteen kinds of medicines. Pinellia (pinellia), Trichosanthes (Trichosanthes), Fritillaria (fritillary), Bletilla (Bletilla), Bletilla (Bletilla) attacks or opposes Aconitum (aconitum). Algae (seaweed), Ji (euphorbia), Sui (gansui), and Daphne (daphne) are all at odds with Cao (licorice). The ginseng (all ginseng such as Panax ginseng, Codonopsis pilosula, Adenophora adenophora, Yuanshen, etc.) Xin (Asarum) and Paeony (Red Paeony and White Paeony) are in conflict with Hellebore.
This sentence comes from the Eighteen Countermeasures of Traditional Chinese Medicine. The formula was first seen in "The Confucian Family Matters" written by the Jin Dynasty physician Zhang Congzheng, and in the "Pearl Sac Supplementary Medical Properties" written by the Yuan Dynasty physician Li Dongyuan. It also contains this motto.
Eighteen anti-drugs list three groups of anti-drugs, namely: licorice anti-gansui, Euphorbia japonicus, seaweed, and daphne; Trichosanthes trichosanthes (whole Trichosanthes trichosanthes, Trichosanthes trichosanthes peel, Trichosanthes trichosanthes kernels, Trichosanthes trichosanthes), Fritillaria fritillary (Sichuan Fritillary scallop, Zhejiang Fritillary scallop), Bletilla chinensis, Bletilla striata; Veratrum anti-ginseng, Adenophora adenophora (Southern Adenophora, Northern Adenophora), Salvia miltiorrhiza, Scrophulariaceae, Sophora flavescens, Asarum, and peony (red and white peony).
The records in subsequent books such as "Compendium of Materia Medica" and "Yaojian" have slight discrepancies, but they are not as good as those recorded in the 18th edition.
Extended information
Doctors in the past have different opinions on whether anti-drugs can be used together. Some doctors believe that using anti-drugs together will increase toxicity and damage the body, so they emphasize that anti-drugs cannot be used together. In addition to the "Shen Nong's Materia Medica" which states "Do not use those who are opposed to each other", the "Compendium of Materia Medica" also states: "On the contrary, we will become enemies and will not be suitable for each other." Sun Simiao said: "The opposites of grass and stones will make people Confusion is as powerful as a sword." It emphasizes that anti-drugs cannot be used together.
Some doctors such as "Yishuo" even describe the symptoms and rescue methods of poisoning caused by the use of opposite drugs. In modern clinical and experimental studies, there are many reports in the literature about examples of poisoning caused by the combined use of anti-drugs such as Fritillaria and Aconitum. Therefore, the "General Rules" of the 1963 edition of the "Chinese Pharmacopoeia" clearly stipulates: "The words "fear, disgust, and reaction" indicate that they should not be used together under normal circumstances.
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Reference: Baidu Encyclopedia-Eighteen Counterattacks