The totally hostile Renaissance and the Reformation did not promote each other. The former promoted the outbreak of the latter, while the latter promoted the spread and development of the former. On the basis of predecessors, Mannetti, a humanist at that time, wrote an article "On the Virtue and Dignity of Human Nature", which broke through the church's view of taking God as the foundation. Later, a group of humanists challenged the monopoly interpretation of the Bible version and scripture of the Roman church, but this was only based on the needs at that time, taking care of and choosing the traditional theological culture from a brand-new angle, and criticizing the traditions that were out of date. In fact, some popes, such as Giovanni di Lorenzo de' Medici, also supported the Renaissance and made some reforms to Catholicism.