No word in English can fully express its implied meaning.
Accurate translation depends on context.
Here are some possible translations:
Forget something.
Stop thinking/worrying about sth.
Be free from sth.
Example:
The only one who can't let me go is my daughter.
The only thing I can't get over is the thought of my daughter.
Colleagues should be able to put it down easily when they disagree.
You shouldn't be upset about your differences with your colleagues at work.