Abstract: In the Song Dynasty, the ancients summarized the important incompatible drugs, namely "eighteen evils" and "nineteen fears". The full text is as follows: eighteen opposites: licorice, spurge, seaweed, Wanhua. Nineteen fears: sulfur is afraid of mirabilite, mercury is afraid of arsenic, stellera chamaejasme is afraid of lithargyrum, croton is afraid of Petunia, clove is afraid of turmeric, aconite kusnezoff monkshood is afraid of rhinoceros horn, tooth nitrate is afraid of three ridges, Guan Guiwei is afraid of lithopone, and ginseng is afraid of trogopterori.

In the Song Dynasty, the ancients summed up important incompatible drugs, namely "eighteen evils" and "nineteen fears". The full text is as follows: eighteen opposites: licorice, spurge, seaweed, Wanhua; Radix Aconiti, Fructus Trichosanthis, Rhizoma Pinelliae, Radix Ampelopsis and Rhizoma Bletillae; Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Asari and Radix Paeoniae. Nineteen fears: sulfur is afraid of mirabilite, mercury is afraid of arsenic, stellera chamaejasme is afraid of lithargyrum, croton is afraid of Petunia, clove is afraid of turmeric, aconite kusnezoff monkshood is afraid of rhinoceros horn, tooth nitrate is afraid of three ridges, laurel is afraid of stone fat, and ginseng is afraid of trogopterori [1]. This Song style of "eighteen evils and nineteen fears" is the anti-fear and anti-evil of its nature, taste and function gradually summed up by the ancients in practice, thus ensuring the safety of medication to a great extent. It has been deeply rooted in the heart of Chinese medicine, and it is still regarded as a taboo for clinical use by most Chinese medicine workers until today. However, due to the need for further observation and research, there are different opinions throughout the ages. The author makes a preliminary analysis of this.

1 drug fear is not always drug fear.

Take licorice as an example. According to the literature, the toxicity of Glycyrrhiza uralensis Fisch, Euphorbia Euphorbia, Guanhua and Kansui Co-soaking group was significantly higher than that of the single soaking group, thus inhibiting the diuretic and laxative effects of the three drugs. However, the author believes that Glycyrrhiza uralensis Fisch is a product for harmonizing various drugs and clearing away heat and toxic materials. If it is used together with some antagonistic Chinese medicines, it can be reconciled.

Without compatibility, there is no opposition and fear.

Some drugs in "eighteen evils and nineteen fears" are completely different, so there is no compatibility problem. For example, veratrum nigrum is emetic, ginseng is qi-invigorating, Salvia miltiorrhiza is nourishing blood, Adenophora adenophora and Scrophularia are nourishing yin and moistening dryness, Asarum is relieving exterior syndrome, and Paeonia lactiflora is nourishing yin; Radix Aconiti Lateralis Preparata, Fritillaria, Fructus Trichosanthis, Radix Ampelopsis, Rhizoma Bletillae, etc. Anyone who is familiar with the theory, methods and prescriptions of traditional Chinese medicine will not use irrelevant resistance and resistance together.

3. Use products that are both "anti" and "scary" when used alone.

Some traditional Chinese medicines are highly toxic, and both of them have bad and terrible consequences. For example, arsenic, mercury and sulfur are all minerals containing arsenic and mercury, which are highly corrosive and cauterizing. If taken orally, it will suddenly cause acute gastroenteritis, burning sensation in the throat, and even lead to poisoning symptoms such as gastric bleeding [2].

From ancient times to the present, there are a large number of examples of using opposing compatibility to deduce miraculous effects.

Some drugs of "eighteen evils and nineteen fears" are different from the actual application, which has also been discussed by doctors in past dynasties. For example, croton in induction pills is used with Petunia; Gansui Banxia decoction is juxtaposed with licorice. Glycyrrhiza uralensis Fisch and seaweed are used together in Sanzhangkuijian decoction and seaweed Yuhu decoction. Mr. Gan, a famous and old modern Chinese medicine doctor, claimed to like to use seaweed and licorice to strengthen the efficacy and treat vocal nodules, breast fibroma and breast hyperplasia [3].

We can't simply deny or affirm "eighteen opposites and nineteen fears". Inheriting and developing Chinese medicine is the sacred mission of Chinese medicine workers.

Five typical cases

Patient, male, 24 years old, student, saw a doctor on March 23, 2004: The patient complained of hoarseness, shortness of breath, lazy speech, feeling foreign body in the throat, red tongue, thin yellow fur and rapid pulse. Laryngoscopy showed "vocal nodules". It is caused by qi stagnation and phlegm obstruction. Treatment should eliminate phlegm and regulate qi. The prescription of Erchen decoction is: tangerine peel 12g, Pinellia ternata 15g, licorice 6g, terminalia chebula 10g, Acorus gramineus 10g, Bupleurum chinense 15g, Fructus Aurantii 12g and Fritillaria/kloc-.

Second diagnosis: The patient complained that the above symptoms were relieved, and Fritillaria, Pinellia ternata and Bombyx Batryticatus were removed from the upper part, and 20g of Radix Rehmanniae, Ophiopogon japonicus 15g, Polygonatum sibiricum 15g and 6g of Lophatherum gracile were added and decocted for 4 doses.

1 week follow-up: the patient's chief complaint symptoms improved, and the liver and kidney functions were normal.

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