Cell English name: CELL is abbreviated as C in the article.
It is composed of protoplasm and nucleus (or pseudonucleus) surrounded by membrane, which is the basic unit of organism structure and function, and also the basic unit of life activities. Cells can proliferate through division, which is the basis of individual development and systematic development of organisms. Cells are either independent living units, or multiple cells form cell groups or tissues, or organs and organisms; Cells can also divide and reproduce; Cell is the basic unit of heredity and has genetic totipotency (plant)
Animal nuclei are omnipotent.
Cytology is a branch of biology that studies the structure and function of cells.
Cell is the basic unit that constitutes the form and function of an organism, and it is composed of many parts. Therefore, the study of cell structure should not only know which parts it is composed of, but also further understand the composition of each part. Accordingly, we should not only know the function of the whole cell, but also understand the functional relationship of each part.
Biological physiological functions and all life phenomena are expressed on the basis of cells. Therefore, cytology is very important for understanding the inheritance, development and physiological functions of organisms, as well as pathology, pharmacology and agricultural breeding as the basis of medical treatment.
The vast majority of cells are very small, beyond the limits of human vision, and observation of cells must use a microscope. So in 1677, when Levin Hook observed the animal's "sperm" with his own simple microscope, he didn't know it was a cell. The word "cell" was named after robert hooke observed cork slices in 1665 and saw cells in cork. In fact, these cells are not living structures, but gaps formed by cell walls, and the term cell has always been used.
In the early stage of cytology, although many tiny objects, such as bacteria and ciliates, were observed with a simple microscope, the main purpose was to observe some developmental phenomena, such as the metamorphosis of butterflies and the structure of sperm and eggs. It was not until 1827 that Bell discovered the eggs of mammals that he began to observe the cells themselves carefully. The achromatic objective lens developed before and after this, the introduction of fuchsin and hematoxylin as dyes to dye the nucleus, and the start of slicer and slicing technology have created favorable conditions for more detailed observation of cells.
German biologists Schleiden and Wang Shi have played a great role in promoting cell research. In 1838, the former describes that cells are produced in a clayey parent material through a process similar to crystallization, and plants are regarded as the * * * isomorphism of cells. Inspired by him, Shi Wan firmly believed that animals and plants are composed of cells, and pointed out the consistency of their structure and growth, and put forward the cell theory in 1839.
At the same time, Czech animal physiologist Pukenye put forward the concept of protoplasm; German zoologist Sebold concluded that protozoa are single-celled. On the basis of studying connective tissue, German pathologist Fairshaw put forward the famous saying that "all cells come from cells" and founded cytopathology.
/kloc-From the mid-9th century to the early 20th century, great progress has been made in the study of cell structure, especially the nucleus. German botanist Strasbourg first described the colored objects in plant cells in 1875, and came to the conclusion that the same plant has a certain number of colored objects; Baranetski described the spiral structure of colored objects in 1880, and the colored particles were found in Pfitzner the next year. It was not until 1888 that Valdeir officially named the colored objects in the nucleus as chromosomes. German scholar Henkin observed the X chromosome in insect sperm cells in 189 1, and Stevens and Wilson observed the Y chromosome in 1902.
German botanist Hoffmeister described the indirect division of plants and animals in 1867 and 1873 respectively. Froemming, a German cytologist, put forward the name of mitosis rather than indirect division after discovering the longitudinal division of chromosomes in 1882, and H described the chromosome distribution during indirect division. After him, Strasbourg divided mitosis into prophase, metaphase, anaphase and anaphase, which is still common until now. He and other scholars also observed the meiosis of plants, and finally distinguished the number of haploid and diploid chromosomes through further research.
The understanding of cytoplasmic structure lags behind that of nucleus or chromosome, and this situation will be improved in the long run. Especially after the beginning of the 20th century, with the cytogenetics research on the chromosome basis of genetic phenomena such as separation, recombination, linkage and exchange, the understanding of chromosomes has been deepened. But at the same time, except for some physiological functions of cell physiology, the understanding of cytoplasmic structure has not made much progress. It was not until the 1940s that the electron microscope was widely used, and a set of techniques for embedding and slicing specimens was gradually improved and great changes took place.
1900 After Mendel's research results were rediscovered, the study of genetics strongly promoted the progress of cytology. Morgan, an American geneticist and embryologist, studied the inheritance of Drosophila and found that individuals who occasionally have white eyes are always male; Combined with the existing knowledge about sex chromosomes, the appearance of white-eyed men is explained, and the genetic phenomenon is explained from the cell. Genetic factors may be located on chromosomes. Cytology and genetics are linked, quantitative and physiological concepts are obtained from genetics, qualitative, material and narrative concepts are obtained from cytology, and cytogenetics is gradually produced.
In 1920, American cytologist Sutton further pointed out that the parallel phenomenon between genetic factors and chromosome behavior inevitably means that genetic factors are located on chromosomes, and mentioned that if two pairs of factors are located on the same chromosome, they may or may not be inherited according to Mendel's law, which shows the concept of linkage and deepens the research on mature division, especially chromosome pairing and chromosome exchange.
In addition, it is also found that radiation and temperature can cause mutation in Drosophila, which is more conducive to the experimental study of chromosomes because of its high mutation frequency. All kinds of mutations caused by radiation, including gene translocation, inversion and deletion, exist in chromosomes. The gene arrangement map of chromosomes can be calculated by crossing mutants with wild types and statistically processing their offspring. The extensive study on the morphology of sex chromosomes has also found a cytological basis for the determination of male and female sex.
In the early 1940s, the technical methods of other disciplines were used in cytological research one after another, which opened up a new situation and formed some new fields. First of all, the application of electron microscope produces ultramicroscopic morphology.
Belgian zoologist Blachais studied the significance of nucleic acid in development by using special staining methods in embryology. Almost at the same time, the Swedish biochemist kasper Song created an ultraviolet cell spectrophotometer to detect the existence of protein, DNA and RNA in cells according to the absorption of certain wavelengths by various substances. Their work has attracted people's attention to the role of nucleic acids in cell growth and differentiation. On the basis of their work, cytochemistry has been developed to study the chemical composition of cells, which can supplement the study of morphology and increase some understanding of cell structure.
In the 1940s, biochemical studies on the functions of various parts of cells were gradually carried out, resulting in biochemical cytology. First, homogenate-mechanically grinding cells in a suitable solution-and differential centrifugation are used to obtain mitochondria, microsomes, hyaluronic acid and nuclei. By studying them separately, we can know the existence and distribution of some substances and enzymes, and where some metabolic processes are carried out. Some studies on mitochondria and microsomes show that many basic biochemical processes are carried out in cytoplasm rather than in nucleus. This method, combined with in-depth morphological research, leads to a deeper understanding of intracellular processes.
Although tissue culture developed greatly in 1930s, it can only cultivate tissue blocks, but not single cells of normal tissues, and its importance has not been fully demonstrated. Using cultured cells, we can study many problems that cannot be studied as a whole, such as cell nutrition, exercise, behavior and the relationship between cells. Almost all kinds of tissues, including some invertebrates, have been cultivated.
Under good culture conditions, the growth of various cells grown from tissue blocks is different. Morphology can be basically divided into three types: epithelium, connective tissue and wandering cells. Sometimes, cultured cells show characteristics that normal tissues do not have in organisms. For example, if the medium contains substances that enhance surface activity, cells of various tissues can acquire phagocytosis. However, they still maintain their unique properties and potential, because if they change the culture environment or move back to the original parts of animals, they can still grow as they are.
It is worth mentioning that the growth of fibroblasts in culture is also affected by substrates. Generally speaking, they grow radially and aimlessly from tissue blocks. However, if the culture medium is artificially placed under tension in a certain direction, or traces are artificially made on the substrate, cells will grow along the direction of tension or along the traces. This phenomenon may explain the functional adaptation of connective tissue and tendon as a whole-they always grow and differentiate in the direction of tension.
It can be seen that the study of cells, the deepening of submicroscopic structure after the use of electron microscope and the deepening of functions after the application of biochemical technology have created conditions for the formation of cell biology-the study of cell life phenomena at the molecular level. Therefore, under the influence of outstanding achievements in molecular genetics and molecular biology, a new discipline of cell biology was quickly formed.
Generally, cells are so small that their faces can only be seen clearly under a microscope. However, there are also units with a length exceeding 1 m.
Neuroanatomists have found that in the nervous system of mammals, some neurons (that is, nerve cells) specialize in motor functions, and their prominent parts can be as long as 1 meter. Their cell bodies are located in the cerebral cortex or spinal cord gray matter, but their protruding ends can reach far away. Located in the cerebral cortex are called pyramidal cells. They have a long process called axon. Axon is a channel used to transmit information, and the motor instructions sent by the brain reach the spinal cord through the brain stem along this line. The cells in the spinal cord that receive instructions from the cerebral cortex are called motor neurons in the anterior horn of the spinal cord. It also has a very long axon, which passes through the cone-shaped tube and reaches the dominated muscle along the spinal nerve, and converts the motor instructions of the brain into the signal of muscle movement, so that the muscle moves with the intention of the brain.
The structure and function of cells are consistent. The distance from cerebral cortex to spinal cord and spinal cord to muscle is very long, so the nerve cells that establish such a long-distance connection between these two parts must have a specific structure, which is why there are such long protrusions. In addition, the bigger an animal is, the longer its motor neurons are.
Human cells
1. The largest cell in human body is a mature egg cell (diameter 0. 1mm).
2. The smallest cell in human body is lymphocyte (6 microns in diameter).
3. The longest-lived cells are nerve cells.
4. The cell with the shortest life span is white blood cell.