In 1962, the National Association of Arts and Letters officially listed O'Keeffe as one of its fifty outstanding members. It was also during this period that the 75-year-old O'Keeffe's vision began to decline. After diagnosis, it was discovered that she had macular degeneration, an eye disease that caused her to gradually lose her central vision and color vision. After settling in Ghost Ranch, O'Keeffe turned to three-dimensional sculpture creation and actively treated her eye disease. In the fall of 1973, young ceramic artist Juan Hamilton came to Ghost Ranch to look for work. O'Keeffe hired him to help with the household chores, and the two soon became close partners.

In addition to creating ceramics, O'Keeffe also began to write memoirs of her life. "The Memoirs of Georgia O'Keeffe" was published in 1976. Perry Miller Adato's documentary of the same name was completed in 1977 and aired on national television. In 1972, O'Keeffe completed her last oil painting "The Beyond" alone. From then on until 1978, he mainly painted with charcoal and watercolor. From 1978 to 1984, most of his paintings were graphite paintings.

In 1984, O'Keeffe moved out of Ghost Ranch to the larger city of Santa Fe in order to obtain better medical care. She passed away at St. Vincent's Hospital on March 6, 1986, at the age of 98. Her ashes were scattered on Pidnon Mountain, where she painted many times during her lifetime, and her ghost ranch can be seen from the mountain. After O'Keeffe's death, she was included in the National List of Distinguished Women. During her lifetime, she was awarded 10 honorary degrees. Many related books featuring her were published one after another. The United States Postal Service also printed her "Red Poppy" as a stamp in 1927.