The meaning of the famous quote of the Mouse and the Weasel is: For many people, vanity is the root of misfortune.

The famous quote about the mouse and the weasel comes from "Aesop's Fables". The details are as follows:

The rats and the weasels went to war. The mice were always defeated every time. They gathered together to discuss and thought that they failed repeatedly because they had no generals. So they voted by a show of hands to elect several mice as generals. These generals wanted to make themselves stand out, so they made horns and tied them on their heads. The war broke out again, and the mice were defeated again. The other mice easily escaped into the hole, but the generals couldn't get in because they had horns on their heads, so they were all eaten by the weasels.

This story tells us that for many people, vanity is the root of misfortune.