The significance of the double helix model not only means that the structure of the DNA molecule has been discovered, but more importantly, it also suggests the replication mechanism of DNA: since adenine (A) always interacts with thymine ( T) pairing, guanine (G) always pairs with cytosine (C), which shows that the base sequences of the two chains are complementary to each other. As long as the base sequence of one chain is determined, the base sequence of the other chain will be determined. The base order is determined. Therefore, you only need to use one chain as a template to synthesize and copy the other chain. Crick had insisted from the beginning that the phrase "the specific pairing principles of DNA immediately call to mind the possible replication mechanisms of the genetic material" be added to the paper published on April 25. He believed that the absence of this sentence would mean that he and Watson "lacked the insight to see this." Shortly after publishing the paper on the double helix structure of DNA, Nature magazine published another paper by Crick shortly afterwards, illustrating the semi-conservative replication mechanism of DNA.