Yes, you can. As long as your radio supports USB, just plug it in with a data cable. Some radios need to be changed according to the settings. The second method is to plug mp3 into the cigarette lighter, see what the frequency of MP3 is, and then adjust the radio frequency to the same as MP3. (For example, if the frequency of MP3 is FM85.00, you can adjust FM85.00 on the radio. )