Broadly speaking, online prescriptions through the medical system are all electronic prescriptions. However, due to the hidden dangers of the electronic prescription issued through the system, such as difficult to confirm the identity of the prescription and the content of the prescription being tampered with, the state promulgated the "Administrative Measures for Internet Diagnosis and Treatment (Trial)", which stipulates that the prescription should sign or seal the electronic prescription by electronic signature.

In the concrete realization of medical institutions, the electronic signature function is integrated with hospital information system (HIS system) or prescription management system to form online circulation and filing of prescriptions, dispensing and taking medicines, and the signature identity can be quickly identified.