Legal analysis: selling a house has nothing to do with his wife's disability. The house can be sold, but it must be notarized with the wife first, and then the transaction and transfer procedures of the house can be handled with the notarized power of attorney.

Legal basis: Article 60 of People's Republic of China (PRC) Urban Real Estate Management Law stipulates that when real estate is transferred or changed, it shall apply to the real estate management department of the local people's government at or above the county level for registration of real estate change, and apply to the land management department of the people's government at the same level for registration of land use right change on the basis of the changed house ownership certificate. After verification by the land administration department of the people's government at the same level, the land use right certificate shall be replaced or changed by the people's government at the same level.

If it is otherwise provided by law, it shall be handled in accordance with the provisions of relevant laws.