If you want to delete your previous personalized signature from the Skype homepage, the steps are as follows:

Close the Skype client. If you want to close the Skype client, right-click the Skype icon in the system tray in the lower right corner of the screen and select Exit.

Press the shortcut key Windows+ R on the keyboard.

Enter %appdata%\skype in the Run dialog box, and then click OK.

Select and open a folder named after your Skype name.

After finding the keyval.db file in the folder, delete or rename it.

When you start the Skype client again, a new keyval.db file will be generated. In this way, all your previous personalized signature information will be deleted from your Skype homepage.