We observed that after six months of resistance training, the aging iconic skeletal muscle "reversed", which is interesting from some angles. As we all know, the result of resistance exercise training is to increase the strength, function and muscle mass of young and old people. In addition, long-term habitual physical activity is associated with a low risk of age-related morbidity and mortality. Previously, we have shown that elderly people who increase cytochrome c oxidase activity and reduce oxidative stress have experienced resistance training for several months. As far as we know, the only other comparable data come from the running ability and myocardial transcription pattern of inbred mice. Compared with younger animals, the mitochondrial level of less active older animals and more active older animals is different. It is possible for us to observe the reversal of mitochondrial aging according to the signature, which can explain that exercise training is only due to the lower routine exercise of the elderly. No, it's a fact. The current research is to choose healthy, active and disease-free elderly people and compare them with the same active young people (relatively ineffective age) in order to avoid this mixed factor. In the future, it will be very important to use cross-sectional sampling of master athletes to decide whether long-term or lifelong exercise can alleviate the aging of human transcription contract.