Paraquat is a highly toxic pesticide with good insecticidal and weeding effects, but it is very toxic. Every year, people commit suicide by taking paraquat, and there is no antidote for it for more than 50 years. Not long ago, Red Sun, a domestic pharmaceutical company, announced the development of a specific drug for paraquat, which is expected to come out within 2-3 years.
According to the data, the chemical name of paraquat is 1- 1- dimethyl -4-4- bipyridine cationic salt, also known as Kuaicao, Kewutrace and Balamo, which was first developed by Imperial Chemical Industry Group of Britain.
The first commercial paraquat was listed in the UK on 1962. Once it came out, it swept the world with its efficient weeding ability and quickly became the second largest herbicide in the world.
As a pesticide, paraquat has a very good effect and little pollution, but many people commit suicide by taking paraquat every year, and its lethal dose is extremely low, about 30-40mg/kg orally. Long-term exposure to more than 5mg% paraquat solution can also cause death. If the skin is damaged, the concentration below this level can also cause fatal poisoning.
Almost 100% of oral paraquat will die, which is very painful. If it comes into contact with the skin, it may be cured, but it will also be seriously injured. The use of paraquat was banned in China on 20 16.
Not long ago, a China pharmaceutical company named Red Sun announced the development of paraquat specific drugs. At present, the structure of small molecular compounds as antidotes has been confirmed, and the synthetic route and process have been verified, reaching the research stage of preclinical candidate compounds. It is estimated that all subsequent research and development processes will take about 2-3 years.
Red sun said that the medicine is an emergency medicine, there is no effective treatment, and it is urgently needed in clinic; At the same time, it is also a truly original new drug and rare disease drug in the world.
According to their published animal experiments, the antidote of paraquat has been tested by the former Institute and Hainan Drug Safety Evaluation Center for more than two years, with several groups and hundreds of animals. The average 30-day survival rate of SD rats and beagle dogs was as high as 95%, while the untreated control group all died after being given the antidote several times the lethal dose of paraquat and gavaged 2, 4 and 6 hours respectively.
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