Tu Youyou was deeply inspired when she read the record of "A handful of Artemisia annua, soaked in a liter of water, wring the juice and drink it all" in the "Emergency Prescriptions" written by Ge Hong, a famous doctor in the Eastern Jin Dynasty, to treat malaria. She repeatedly pondered this record. The ancient records did not use the traditional decoction method. Instead, they soaked Artemisia annua in water and "wrung out the juice." Tu Youyou suddenly realized that the conventional high-temperature boiling process might destroy the effective The biological activity of ingredients also involves the issue of medicinal sites. To do this, she redesigned the extraction protocol. The low boiling point solvent ether was used to extract the leaves of Artemisia annua, and the ineffective acidic part was removed, so that the potency of the resulting neutral extract against rat malaria was significantly improved. It has been clinically tested on patients with vivax and falciparum malaria, and all are effective.