Eighteen anti-drugs first appeared in-He's The Scholars, and listed three groups of opposing drugs, namely licorice, Euphorbia, seaweed and Daphne genkwa. Radix Aconiti Lateralis Preparata, Rhizoma Pinelliae, Fructus Trichosanthis, Bulbus Fritillariae Cirrhosae, Radix Ampelopsis and Trichosanthis Radix.

Materia Medica clearly states eighteen kinds of contradictions.

Half-baked shellfish and attacking Wu

Algae and halberds compete for grass.

Ginseng Xin Shao betrayed Veratrum and went away; Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Radix Sophorae Flavescentis, Asari, Radix Paeoniae Alba (Radix Paeoniae Rubra, Radix Paeoniae Alba