Orochimaru
Judging from the Ninjutsu used by Mitsuki, he should have the gene of Uncle Snake, otherwise he would not be treated as a "son" by orochimaru. As one of the few people with high IQ in Huo Ying, orochimaru certainly hopes that Mitsuki can inherit his high IQ. Moreover, Uncle Snake's genes have undergone many transformations of his own, and there must be advantages that ordinary people do not have. Even if Mitsuki doesn't have orochimaru's ability to live forever, it may be because of Uncle Snake's genes, and his physical fitness and adaptability will be stronger than ordinary people.
Yakushi Kabuto
As one of orochimaru's proud disciples, Yakushi Kabuto's IQ and achievements are not lower than those of Uncle Snake. He not only acquired the abilities of orochimaru and his subordinates, but also cultivated the immortal mode in Tommy Tam Cave, while orochimaru did not cultivate the immortal mode himself. However, Mitsuki will practice immortal mode in Tommy Tam cave, which shows that Mitsuki's genes probably contain Yakushi Kabuto's genes. And Yakushi Kabuto used to be a messenger of orochimaru, so it is not difficult to get Yakushi Kabuto's genes.
Senju Hashirama
Senju Hashirama's cells can be said to be the strongest props in Huo Ying. Because he inherited Ootutuki Hagoromo's immortal body, his cells have powerful chakra and the ability of rapid recovery and regeneration. He is also the only person in Huo Ying who can use wood to dodge. Others can use wooden shelters, because there are spaces between columns. Even the strongest illusion "Other Gods" with extremely long cooling time can be used for the second time in a short time as long as there is a chakra between columns. Orochimaru must have intergenic genes, otherwise he can't transform Yamato and improve pollution.
Senju Tobirama
It's normal to add Senju Hashirama's genes, but many people will ask why Mitsuki may also have mesenchymal genes. Although there is no blood barrier between leaves and pillars, his accomplishments in developing Ninjutsu are not as good as orochimaru's, and he has also developed many powerful Ninjutsu techniques, such as multiple shadows, pollution metempsychosis, riding enlightenment symbols and so on. It is also possible for orochimaru to insert genes between leaves. Moreover, from the appearance of Mitsuki's brother "Rogge" (that is, the artificial man made by orochimaru before Mitsuki), it is very similar to the one between leaves, which also proves that orochimaru probably added the gene between leaves to Mitsuki.
Who else do you think has genes in Mitsuki? Welcome to leave a message in the comments section below.