In February and March of the same year, the Qing government sent Governor Yungui, Governor Fu Kang 'an of Sichuan and Governor of Guangdong and Guangxi, and Governor Fu Ning of Huguang to lead more than 100,000 troops in seven provinces to suppress them in different ways. The insurgents attacked everywhere with the tactics of "the enemy has 10,000 soldiers, I have 10,000 mountains, they come and I go, they go and I come". In August, Wu wiped out more than 6,000 people led by Funing in the battle of dogs worshiping rocks in Ganzhou, and Funing was spared. Wu spent half his life in the big bird's nest river in Fenghuang Hall, blocking Fu Kang 'an for half a year. In August, the rebel army established Wu Weimiao as the general. In order to get rid of the predicament, the Qing government took measures to suppress and comfort. In September, Wu Bansheng was captured by spies. 12, Wu was captured in August for betraying a traitor. In June of the first year of Jiaqing (1796), Shi was lured to Aoxi by traitors and captured. As the leaders of the uprising were killed one after another, the insurgents began to retreat. In September, the Qing government appointed Eldenbao as commander-in-chief to replace Fu Kang 'an and He Lin, who died in succession in the army, and mobilized heavy troops to besiege the insurgents. In December, Shilong village, the last stronghold of the rebels, fell, Deng died in Guiyupo, and the uprising failed. In the fifth year of Xianfeng (1855), under the influence of the Taiping Heavenly Kingdom Uprising, a large-scale anti-Qing uprising broke out among Miao farmers in Guizhou, led by Miao farmer leader Zhang Xiumei. Zhang Xiumei, Bao Dafang and others gathered in the squire's bow, and vowed to capture the squire hall city on March 15th, the fifth year of Xianfeng, kill the state officials and launch an armed uprising.
The rebels captured most of the flood-fighting castles in southeastern Guizhou. After three years of fighting, they successively captured Kaili, Shibing, Qingjiang, Taigong, Ping Huang, Guzhou, Duyun and other counties. In February of the seventh year of Xianfeng (1857), the Qing army was defeated in Dingjiabao near Duyun, forcing Yin Xiao, the governor of Guizhou, to commit suicide. The following year, the rebel army led by Zhang Xiumei took control of most areas where Miao people lived in southeastern Guizhou, set up official posts, reclaimed wasteland, confiscated the land of landlords and distributed it to farmers for farming. During this period, Miao farmers in Guiding, led by Pan Mingjie brothers, also rose up and attacked Longli, Guiding, Guiyang and other towns many times, constantly attacking the Qing army. In August of the ninth year of Xianfeng (1859), the rebels captured Weng' an County, and in January of the tenth year of Xianfeng (186 1), they captured Pingyao Prefecture (now Fuquan).
In the same year, Miao farmers in northwest Guizhou, led by Tao Xinchun, took the junction of Hezhang, Bijie and Zhenxiong counties in Yunnan as the base area, cooperated with Zeng Guangyi of the Taiping Heavenly Kingdom to attack Dadingfu City and surrounded Bijie County. In the second year of Tongzhi (1863), Yan Dawu surrounded Guiyang with the Miao People's Army and Taiping Army under his guidance. Yan Dawu led his troops into Anshun and Dading, and fought with the Qing army as the center. After the failure of the Taiping Heavenly Kingdom, the Qing government concentrated on suppressing the uprising. In the five years of Tongzhi, Li Pai, the governor of Hunan Province, and Li Yinxiang's army entered Guizhou with 20,000 troops, which were magnanimous and resisted by nine white-collar soldiers. The Qing government reassigned Xi Bao Tian instead of Zhao Chen, who did not perform well in the encirclement and suppression campaign. Since then, the Miao peasant uprising has turned into a period of hard struggle.
In the seventh year of Tongzhi, the Qing government concentrated its forces in Hunan, Sichuan and Guizhou provinces, and Xi Baotian, Tang Jiong and Zhang Wende led three roads to besiege the insurgents. In the summer of the 11th year, the uprising leaders such as Jiu Dabai, Bao Dafang and Tao Xinchun died one after another, and Zhang Xiumei, Yan Dawu, Gao He and Yang Daliu were captured one after another. At this point, the Miao uprising in Guizhou, which lasted for 18 years, failed.