From 65438 to 0958, Blake joined ICI Pharmaceutical Co., Ltd. Six years later, he joined GlaxoSmithKline Pharmaceutical Company (Smith, Kline &; French laboratory), 1973. From 1973 to 1977, he is a professor of pharmacology at University College London. 1978- 1984 was appointed as the director of therapy research of Wellcome pharmaceutical company. 1984, Blake, who wanted to return to academics, accepted the invitation of King's College School of Medicine, University of London and became a professor of pharmacology. Eight years later, he was appointed as the President of university of dundee, and has been in office ever since.

Blake married his wife Hilary Vaughan in 1946 * * and they had a daughter named Stephanie. 1986, Hillary passed away. Blake was elected as a member of the Royal Society of London in 1976, knighted in 198 1 and won the Nobel Prize in Physiology or Medicine in 1988.