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The predecessor of Nanjing Senior High School in Jiangsu Province was the "Nanjing Academy" founded by Huang Tifang, a scholar in Jiangsu Province, in the eighth year of Guangxu. At that time, Zuo Zongtang, Minister of the Ministry of War of the Qing Dynasty and Governor of Liangjiang, reported to the Yangtze River Navy at Jingkou, The former site of the two offices in Guerrilla Town and the 20,000 taels of silver co-organized the academy. The academy was named after Zhu Xi's famous saying, "The learning from the south is to obtain its essence."

Jiangsu Nanjing Senior High School is one of the first batch of key middle schools in Jiangsu Province, a model middle school in Jiangsu Province, the first batch of national-level model senior high schools that passed the acceptance test in Jiangsu Province, a national-level experimental school of modern education technology, and a Harvard University student social practice base. In 2007, Nanjing Middle School was awarded the title of Advanced School in the National Education System by the Ministry of Education and the Ministry of Personnel.